# FDA Approves Estradiol Transdermal Patch from Encube Ethicals Encube Ethicals, Inc. received FDA approval for its generic estradiol transdermal patch (ANDA218214), expanding the competitive landscape in hormone replacement therapy and potentially increasing treatment accessibility while putting downward pricing pressure on the established estradiol patch market. The approval adds another player to the growing roster of generic HRT options as demand for estradiol products continues to rise among menopausal women seeking non-oral delivery alternatives.