Pfizer Chief Financial Officer Dave Denton is stepping down on August 15, 2026 to pursue an opportunity in consumer goods, with Senior Vice President Cecile Guegan assuming the interim CFO role effective August 16 while the company conducts a comprehensive search for a permanent successor. The transition is relatively orderly with Denton and Guegan working together to ensure continuity during a period when Pfizer has executed major acquisitions including Seagen, Biohaven, and Metsera.