PBGENE-HBV shows first clinical evidence of cccDNA elimination in hepatitis B patients

Precision BioSciences announced late-breaking clinical data from the ELIMINATE-B study demonstrating that PBGENE-HBV directly eliminated cccDNA with a 10-fold reduction in viral transcripts and achieved pgRNA loss in 100% of treated patients. The data represent a potential breakthrough in hepatitis B treatment by directly targeting the virus's root cause rather than providing lifelong suppression.