On September 25, 2026, Jaguar Health, Inc. entered into privately negotiated exchange agreements with Streeterville Capital, LLC to settle a portion of a previously issued promissory note.

The transaction involves the issuance of 481,584 shares of the Company’s common stock to Streeterville in exchange for a reduction of $3,400,000 from the outstanding balance of the 2021 Note. The 2021 Note, originally issued on January 19, 2021, had an original principal amount of $6,220,812.50.

The shares issued in this exchange were sold pursuant to an exemption from registration under Section 3(a)(9) of the Securities Act of 1933. As of the date of the report, Jaguar Health had approximately 1,945,542 shares of common stock issued and outstanding.