22nd Century Group, Inc. filed a prospectus supplement with the Securities and Exchange Commission on October 23, 2026, to support its ongoing at-the-market stock offering. The filing amends the company's Registration Statement on Form S-3 (Registration No. 333-294792), which permits the sale of up to $18,800,000 shares of common stock.

The offering is conducted pursuant to a Sales Agreement with Needham & Company, LLC. During the month of October 2026, the company executed sales under this agreement, issuing 15,785,757 shares of common stock. These sales generated gross proceeds of approximately $4.7 million.

As of the date of the filing, the company reported having 19,202,198 shares of common stock outstanding. The filing also includes an opinion from Foley & Lardner LLP regarding the validity of the shares to be sold.